THE EFFECT OF VITAMIN C ON PHARMACOKINETIC PARAMETERS OF CHLOROQUINE IN HEALTHY HUMAN VOLUNTEERS
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 5000
ABSTRACT
This study was undertaken to compare the effect of vitamin C on the pharmacokinetics of chloroquine using human volunteers. Quality control studies for both chloroquine and vitamin C; identification test, assay, weight variation, friability, disintegration time and dissolution rate were carried out according to BP 2009. Jayanathi et al., 1994 method was adopted and validated based on ICH guideline for this study. Calibration curve was constructed within the range of 2 – 10 µg/ml and validated. The adopted method was then employed in determining the effect of vitamin C on the pharmacokinetics parameters (Cmax, Tmax, Ka, Ke, t1/2a, t1/2e, Cl, Vd, lag time and AUC) of chloroquine using human volunteers of 30 years and above and the study was divided into three phases with a washout period of three weeks. Both chloroquine and vitamin C used for this study were found to have the labeled active ingredient. They all passed the assay test as they were within the acceptable limits 95 – 105 %. Weight variation was conducted for both chloroquine and vitamin C and they all passed as their percentage mean deviation was less than 5 %. Similarly, both drugs passed the friability test which was less than 1%. Disintegration tests for both drugs reveals that they disintegrate in less 5 mins and also both chloroquine and vitamin C passed the dissolution rate as more than 70 % of the active ingredient was released in 30 mins. The percentage recovery of the method was within the accepted range of 98 – 102 %. Calibration curve was linear within the range of 2 – 10 µg/ml as the correlation coefficient was 0.9905. The regression equation was y= 0.001x + 0.120. When chloroquine was administered alone no significant difference (p<0.05) at lower values was observed, however, on coadministration of chloroquine and vitamin C no significant difference (p<0.05) at lower values was also observed, except for clearance (Cl) which was statistically significant vii (p<0.05) at lower values. On the other hand, when an hour delayed administration of chloroquine and vitamin C no significant difference (p<0.05) was observed, except for clearance (Cl) which was also statistically significant (p<0.05) at lower values. This finding indicates that vitamin C may influence the pharmacokinetics of chloroquine when coadministered together depending on the time of administration of the two drugs.
Related Project Materials
Effectiveness of Budgeting Practices in Promoting SME Growth in Minna LGA
Background of the Study
Budgeting is a critical practice for Small and Medium Enterpri...
GLOBAL ECONOMIC RECESSION: ITS IMPACT ON THE BANKING INDUSTRY IN NIGERIA
ABSTRACT
The crisis that has rocked the Global economy in the past few year has been nothing but of great interest to go...
An Examination of the Relationship Between Substance Abuse and Violent Behavior in Psychiatric Patients: A Case Study of Federal Neuropsychiatric Hospital, Benin City, Edo State
Background of the Study
Substance abuse and psychiatric disorders are often comorbid conditions, with s...
Development of a Computational Biology Model for Predicting Genetic Risk Factors in Epilepsy: A Case Study of Bauchi State University, Gadau, Bauchi State
Background of the Study :
Epilepsy is a complex neurological disorder influenced by both genetic predispositions and enviro...
Holmes: An Open-source Image Forensics Toolkit
ABSTRACT
Digital images continue to be ever-present in our daily lives as means of conveying information. With the avail...
THE IMPACT OF CAREER-ORIENTED ELECTIVES IN VOCATIONAL EDUCATION
ABSTRACT: The Impact of Career-Oriented Electives in Vocational Education explores the influence of specialized elective courses on vocational stud...
Exploring the Role of Television News in Influencing Youth Political Activism in Kaiama Local Government Area, Kwara State
Chapter One: Introduction
1.1 Background of the Study...
An assessment of forensic anthropology in solving cases of buried homicide victims in Oyo East Local Government Area, Oyo State
Background of the Study
Buried homicide cases present unique challenges in forensic investigations, particularly in region...
Implementation of a Bioinformatics Platform for Studying Plant Genetics and Crop Improvement: A Case Study of Federal University, Lokoja, Kogi State
Background of the Study :
The global challenge of food security necessitates innovative approaches in plant genetics and cr...
A comparative study of conversion optimization on online sales performance: Evidence from a tech retailer in Kano, Nigeria
Background of the study
Conversion optimization is fundamental for enhancing online sales performance, especially for tech retailers oper...
